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Tuesday 14 February 2006
Consider nitrofurantoin in bacterial-resistance era
Nitrofurantoin should be considered as a fluoroquinolone-sparing agent for women with mild to moderate symptoms of uncomplicated cystitis, Dr. Thomas M. Hooton said at the annual Interscience Conference on Antimicrobial Agents and Chemotherapy.
Nitrofurantoin, first approved in 1953 for the treatment of urinary tract infection (UTI), has been overshadowed in the last several decades, first by trimethoprim-sulfamethoxazole (TMP-SMX), and more recently by fluoroquinolones. But the old drug's role is being reexamined in light of increasing antimicrobial resistance.